Affiliation:
1. Departments of Biochemistry and Medicine, The Bowman Gray School of Medicine, Winston-Salem, North Carolina 27103
Abstract
The addition of either ascorbic acid or dehydroascorbic acid to a suspension of polymorphonuclear leukocytes caused a dramatic increase in the resting hexose monophosphate shunt activity. A sequence of reactions involving dehydroascorbate, reduced glutathione, and reduced nicotinamide adenine dinucleotide phosphate is described to explain this stimulation. This sequence could provide an alternate method of producing H
2
O
2
and a bactericidal mechanism which is independent of myeloperoxidase.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Cited by
47 articles.
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