Stimulation of Leukocyte Hexose Monophosphate Shunt Activity by Ascorbic Acid

Author:

Cooper M. Robert1,McCall Charles E.1,DeChatelet Lawrence R.1

Affiliation:

1. Departments of Medicine and Biochemistry, The Bowman Gray School of Medicine, Winston-Salem, North Carolina 27103

Abstract

Ascorbic acid in vitro markedly stimulates the hexose monophosphate shunt in normal human neutrophils, rabbit alveolar macrophages, and in neutrophils from a patient with chronic granulomatous disease.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Reference7 articles.

1. Leukocyte oxidase: defective activity in chronic granulomatous disease;Baehner R. L.;Science,1967

2. Complete deficiency of leukocyte glucose-6-phosphate dehydrogenase with defective bactericidal activity;Cooper M. R.;J. Clin. Invest.,1970

3. Studies of the metabolic activity of leukocytes from patients with a genetic abnormality of phagocytic function;Holmnes B.;J. Clin. Invest.,1967

4. Chronic granulomatous disease in females. A deficiency of leukocyte glutathione peroxidase;Holmes B.;N. Engl. J. Med.,1970

5. Effects of sulfhydryl inhibition on red blood cells. III. Glutathione in the regulation of the hexose monophosphate pathway;Jacob H. S.;J. Biol. Chem.,1966

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