Daptomycin Exerts Bactericidal Activity without Lysis of Staphylococcus aureus-Reference-Cited by-同舟云学术

Daptomycin Exerts Bactericidal Activity without Lysis of Staphylococcus aureus

Published:2008-06 Issue:6 Volume:52 Page:2223-2225
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Cotroneo Nicole¹,Harris Robert²,Perlmutter Nancy³,Beveridge Terry²⁴,Silverman Jared A.¹

Affiliation:

1. Cubist Pharmaceuticals, Inc., 65 Hayden Avenue, Lexington, Massachusetts 02421

2. University of Guelph, Guelph, Ontario, Canada N1G 2W1

3. Howard M. Shapiro, M.D., P.C., West Newton, Massachusetts

4. MicroTEM, Inc., Elora, Ontario, Canada N0B 1S0

Abstract

ABSTRACT The ability of daptomycin to produce bactericidal activity against Staphylococcus aureus while causing negligible cell lysis has been demonstrated using electron microscopy and the membrane integrity probes calcein and ToPro3. The formation of aberrant septa on the cell wall, suggestive of impairment of the cell division machinery, was also observed.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01410-07

Reference13 articles.

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