Fenticonazole Activity Measured by the Methods of the European Committee on Antimicrobial Susceptibility Testing and CLSI against 260 Candida Vulvovaginitis Isolates from Two European Regions and Annotations on the Prevalent Genotypes-Reference-Cited by-同舟云学术

Fenticonazole Activity Measured by the Methods of the European Committee on Antimicrobial Susceptibility Testing and CLSI against 260 Candida Vulvovaginitis Isolates from Two European Regions and Annotations on the Prevalent Genotypes

Published:2009-05 Issue:5 Volume:53 Page:2181-2184
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Antonopoulou Stavroula¹²³,Aoun Michel²,Alexopoulos Evangelos C.⁴,Baka Stavroula¹,Logothetis Emanuel¹,Kalambokas Theodoros³⁵,Zannos Andreas³⁶,Papadias Konstantine⁵,Grigoriou Odysseas⁵,Kouskouni Evangelia¹,Velegraki Aristea³

Affiliation:

1. Department of Bacteriology and Biochemistry, University of Athens, Aretaieion Hospital Athens, Athens, Greece

2. Institute Jules Bordet, ULB, Brussels, Belgium

3. Mycology Laboratory, Medical School, National and Kapodistrian University of Athens, Athens, Greece

4. Department of Public Health, Medical School, University of Patras, Patras, Greece

5. Second Department of Obstetrics and Gynecology, University of Athens, Aretaieion Hospital, Athens, Greece

6. Microbiology Laboratory, 401 Military Hospital, Athens, Greece

Abstract

ABSTRACT The activity of fenticonazole was studied against 260 West and Southeast European vulvovaginal candidiasis isolates, and low MICs were displayed. Fenticonazole was assessed by European Committee on Antimicrobial Susceptibility Testing and CLSI microdilution methods for the first time, and the results showed excellent agreement (97%) and significant interclass correlation coefficient ( P < 0.0001). Also, the levels of agreement for the results for itraconazole, fluconazole, and ketoconazole were 84%, 90%, and 98% ( P < 0.0001), respectively. Multilocus typing by PCR fingerprinting and subsequent cluster analysis delineated geographically associated alignments for Candida albicans and fluconazole resistance-related clusters for Candida glabrata .

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01413-08

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