Epigenetic Changes Induced by Bacteroides fragilis Toxin-Reference-Cited by-同舟云学术

Epigenetic Changes Induced by Bacteroides fragilis Toxin

Published:2019-06 Issue:6 Volume:87 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Allen Jawara¹,Hao Stephanie²,Sears Cynthia L.¹³⁴,Timp Winston²^ORCID

Affiliation:

1. Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

2. Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

3. Bloomberg-Kimmel Institute for Immunotherapy, Johns Hopkins Medicine Institutions, Baltimore, Maryland, USA

4. Department of Oncology, Johns Hopkins Medicine Institutions, Baltimore, Maryland, USA

Abstract

Enterotoxigenic Bacteroides fragilis (ETBF) is a Gram-negative, obligate anaerobe member of the gut microbial community in up to 40% of healthy individuals. This bacterium is found more frequently in people with colorectal cancer (CRC) and causes tumor formation in the distal colon of multiple intestinal neoplasia ( Apc min/+ ) mice; tumor formation is dependent on ETBF-secreted Bacteroides fragilis toxin (BFT).

Funder

Bloomberg Philanthropies

HHS | National Institutes of Health

Johns Hopkins Department of Medicine

Howard Hughes Medical Institute

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00447-18

Reference40 articles.