Identification of a Functional Small Noncoding RNA of African Swine Fever Virus

Author:

Dunn Laura E. M.12,Ivens Alasdair3,Netherton Christopher L.1,Chapman David A. G.1,Beard Philippa M.12ORCID

Affiliation:

1. The Pirbright Institute, Pirbright, Surrey, United Kingdom

2. The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Roslin, Midlothian, United Kingdom

3. Centre for Immunity, Infection and Evolution, University of Edinburgh, Edinburgh, United Kingdom

Abstract

African swine fever (ASF) poses a major threat to pig populations and food security worldwide. The disease is endemic to Africa and Eastern Europe and is rapidly emerging into Asia, where it has led to the deaths of millions of pigs in the last 12 months. The development of safe and effective vaccines to protect pigs against ASF has been hindered by lack of understanding of the complex interactions between ASFV and the host cell. We focused our work on characterizing the interactions between ASFV and sncRNAs. Although comparatively modest changes to host sncRNA abundances were observed upon ASFV infection, we discovered and characterized a novel functional ASFV-encoded sncRNA. The results from this study add important insights into ASFV host-pathogen interactions. This knowledge may be exploited to develop more effective ASFV vaccines that take advantage of the sncRNA system.

Funder

UKRI | Biotechnology and Biological Sciences Research Council

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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