Affiliation:
1. Division of Infectious Diseases, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia 23298-0049
Abstract
ABSTRACT
The in vitro antifungal activity of a new triazole derivative, voriconazole, was compared with those of itraconazole and amphotericin B against 67 isolates of
Aspergillus flavus
,
Aspergillus fumigatus
,
Bipolaris
spp.,
Fusarium oxysporum
,
Fusarium solani
,
Pseudallescheria boydii
,
Rhizopus arrhizus
,
Blastomyces dermatitidis
,
Histoplasma capsulatum
, and
Sporothrix schenckii
. The in vitro activities of voriconazole were also compared with those of amphotericin B, fluconazole, and itraconazole against 189 isolates of emerging and common yeast pathogens of
Blastoschizomyces capitatus
,
Candida
(13 species),
Cryptococcus neoformans
,
Hansenula anomala
,
Rhodotorula rubra
,
Saccharomyces cerevisiae
,
Sporobolomyces salmonicolor
, and
Trichosporon beigelii
. MICs were determined according to a procedure under evaluation by the National Committee for Clinical Laboratory Standards (NCCLS) for broth microdilution testing of filamentous fungi and by the NCCLS M27-A broth microdilution method for yeasts. The in vitro activities of voriconazole were similar to or better than those of itraconazole and amphotericin B against
Aspergillus
spp.,
Fusarium
spp., and
P. boydii
as well as against
B. dermatitidis
and
H. capsulatum
. The activities of voriconazole were also comparable to or better than those of amphotericin B, fluconazole, and itraconazole against most species of yeasts tested. Exceptions were certain isolates of
R. rubra
and
S. salmonicolor
. These results suggest that voriconazole has a wide spectrum of activity in vitro; its effectiveness in the treatment of human mycoses is under evaluation in clinical trials.
Publisher
American Society for Microbiology
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1995
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American Society for Microbiology
Washington D.C
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Abstracts of the 35th Interscience Conference on Antimicrobial Agents and Chemotherapy.
1995
126
American Society for Microbiology
Washington D.C
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