In vitro studies of two triazole antifungal agents (voriconazole [UK-109,496] and fluconazole) against Candida species-Reference-Cited by-同舟云学术

In vitro studies of two triazole antifungal agents (voriconazole [UK-109,496] and fluconazole) against Candida species

Published:1996-08 Issue:8 Volume:40 Page:1948-1949
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Barry A L¹,Brown S D¹

Affiliation:

1. Clinical Microbiology Institute, Tualatin, Oregon 97062, USA.

Abstract

A new triazole derivative (voriconazole or UK-109,496) and fluconazole were tested against 249 isolates of Candida spp. representing six species. Voriconazole was 10 to 100 times more potent than fluconazole. Strains with decreased susceptibility to fluconazole were inhibited by relatively low concentrations of voriconazole.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.40.8.1948

Reference10 articles.

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3. Dupont B. D. Denning H. Lode S. Yonren P. Troke and N. Sarantris. 1995. UK-109 496 a novel wide-spectrum triazole derivative for the treatment of fungal infections: clinical efficacy in chronic invasive aspergillosis abstr. F81 p. 127. In Abstracts of the 35th Interscience Conference on Antimicrobial Agents and Chemotherapy. American Society for Microbiology Washington D.C.

4. Hitchcock C. A. G. W. Pye G. P. Oliver and P. F. Troke. 1995. UK-109 496 a novel wide-spectrum triazole derivative for treatment of fungal infections: antifungal activity and selectivity in vitro abstr. F72 p. 125. In Abstracts of the 35th Interscience Conference on Antimicrobial Agents and Chemotherapy. American Society for Microbiology Washington D.C.

5. McGinnis M. R. L. Pasarell and C. R. Cooper Jr. 1995. In vitro susceptibility of clinical mould isolates to UK-109 496 amphotericin B fluconazole and itraconazole abstr. E76 p. 99. In Abstracts of the 35th Interscience Conference on Antimicrobial Agents and Chemotherapy. American Society for Microbiology Washington D.C.

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