Population Pharmacokinetic and Pharmacodynamic Analysis of Valganciclovir for Optimizing Preemptive Therapy of Cytomegalovirus Infections in Kidney Transplant Recipients-Reference-Cited by-同舟云学术

Population Pharmacokinetic and Pharmacodynamic Analysis of Valganciclovir for Optimizing Preemptive Therapy of Cytomegalovirus Infections in Kidney Transplant Recipients

Published:2023-02-23 Issue: Volume: Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Cojutti Pier Giorgio¹²^ORCID,Heffernan Aaron J.³^ORCID,Tängdén Thomas⁴^ORCID,Della Siega Paola⁵,Tascini Carlo⁵,Roberts Jason A.³⁶⁷⁸⁹^ORCID,Pea Federico¹²^ORCID

Affiliation:

1. Department of Medical and Surgical Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy

2. Clinical Pharmacology Unit, IRCCS Azienda Ospedaliero Universitaria di Bologna, Bologna, Italy

3. Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Herston, Queensland, Australia

4. Department of Medical Sciences, Uppsala University, Uppsala, Sweden

5. Infectious Diseases Clinic, Santa Maria della Misericordia University Hospital of Udine, ASUFC, Udine, Italy

6. Department of Pharmacy, Royal Brisbane and Women’s Hospital, Brisbane, Queensland, Australia

7. Herston Infectious Diseases Institute (HeIDI), Metro North Health, Brisbane, Queensland, Australia

8. Department of Intensive Care Medicine, Royal Brisbane and Women’s Hospital, Brisbane, Queensland, Australia

9. Division of Anaesthesiology Critical Care Emergency and Pain Medicine, Nîmes University Hospital, University of Montpellier, Nîmes, France

Abstract

This study aimed to develop a population pharmacokinetic/pharmacodynamic (PK/PD) model of valganciclovir for preemptive therapy of cytomegalovirus (CMV) infection in kidney transplant patients. A population PK/PD model was developed with Monolix.

Funder

Australian National Health and Medical Research Coucnil

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.01665-22

Reference32 articles.

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2. Epidemiology, risk factors, and outcomes associated with cytomegalovirus in adult kidney transplant recipients: A systematic literature review of real‐world evidence

3. Correlation of Cytomegalovirus (CMV) Disease Severity and Mortality With CMV Viral Burden in CMV-Seropositive Donor and CMV-Seronegative Solid Organ Transplant Recipients

4. Improving Outcomes for Solid-Organ Transplant Recipients At Risk from Cytomegalovirus Infection: Late-Onset Disease and Indirect Consequences

5. Antiviral medications for preventing cytomegalovirus disease in solid organ transplant recipients

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