Bone and Joint Tissue Penetration of the Staphylococcus -Selective Antibiotic Afabicin in Patients Undergoing Elective Hip Replacement Surgery

Author:

Menetrey Annick1,Janin Annick1,Pullman John2,Overcash J. Scott3,Haouala Amina1,Leylavergne François1,Turbe Laurent4,Wittke Frederick1,Nicolas-Métral Valérie1

Affiliation:

1. Debiopharm International SA, Lausanne, Switzerland

2. St. James Healthcare, SCL Health, Butte, Montana, USA

3. Sharp Grossmont Hospital, La Mesa, California, USA

4. Atlanbio, Saint-Nazaire, France

Abstract

Afabicin (formerly Debio 1450, AFN-1720) is a prodrug of afabicin desphosphono (Debio 1452, AFN-1252), a novel antibiotic in development which targets the staphylococcal enoyl-acyl carrier protein reductase (FabI) and exhibits selective potent antibacterial activity against staphylococcal species, including methicillin-resistant Staphylococcus aureus . As part of clinical development in bone and joint infections, a distribution study in bone was performed in 17 patients who underwent elective hip replacement surgery.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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