Recovery of Applied Human Leukocyte Interferon from the Nasal Mucosa of Chimpanzees and Humans

Author:

Johnson Paul E.1,Greenberg Stephen B.,Harmon Maurice W.,Alford Bobby R.,Couch Robert B.

Affiliation:

1. Department of Otorhinolaryngology and Communicative Sciences, Baylor College of Medicine, Houston, Texas 77030

Abstract

Intranasally applied human leukocyte interferon was recovered locally in 9 of 10 chimpanzees and 3 of 3 human volunteers tested. A 5- to 50-fold reduction in interferon was observed over 60 min.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Reference6 articles.

1. Physiology of the nose;Abramson M.;Otolaryngol. Clin. North Am.,1973

2. Atraumatic biopsy of nasal mucosa;Alford B. R.;Arch. Otolaryngol.,1969

3. Cantell K. S. Hirnonen K. E. Mogensen and L. Pyhala. 1974. The production and use of interferon for the treatment and prevention of human virus infections p. 3. In C. Waymouth (ed.) In vitro monograph no. 3. The Tissue Culture Association Rockville Md.

4. Inhibition of respiratory virus infection by locally applied interferon;Merigan T. C.;Lancet,1973

5. Clearance of inhaled particles from the human nose;Proctor D. F.;Arch. Intern. Med.,1973

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1. The Use of Interferons in Respiratory Viral Infections;Viral and Other Infections of the Human Respiratory Tract;1996

2. Intranasal Interferons for Control of Respiratory Viral Infections;Clinical Aspects of Interferons;1988

3. Nasal Delivery of Polypeptides I: Nasal Absorption of Enkephalins in Rats;Journal of Pharmaceutical Sciences;1985-04

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5. Clinical Use of Interferons: Localized Application in Viral Diseases;Interferons and Their Applications;1984

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