High-Throughput Mutagenesis and Cross-Complementation Experiments Reveal Substrate Preference and Critical Residues of the Capsule Transporters in Streptococcus pneumoniae-Reference-Cited by-同舟云学术

High-Throughput Mutagenesis and Cross-Complementation Experiments Reveal Substrate Preference and Critical Residues of the Capsule Transporters in Streptococcus pneumoniae

Published:2021-12-21 Issue:6 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Chua Wan-Zhen¹^ORCID,Maiwald Matthias¹²³^ORCID,Chew Kean Lee⁴,Lin Raymond Tzer-Pin¹⁴⁵,Zheng Sanduo⁶⁷^ORCID,Sham Lok-To¹^ORCID

Affiliation:

1. Infectious Diseases Translational Research Programme and Department of Microbiology and Immunology, National University of Singapore, Singapore

2. Department of Pathology and Laboratory Medicine, KK Women’s and Children’s Hospital Singapore

3. Duke-NUS Graduate Medical School, National University of Singapore, Singapore

4. Department of Laboratory Medicine, National University Hospital, Singapore

5. National Public Health Laboratory, Ministry of Health, Singapore

6. National Institute of Biological Sciences, Beijing, China

7. Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing, China

Abstract

All licensed pneumococcal vaccines target the capsular polysaccharide (CPS). This layer is highly variable and is important for virulence in many bacterial pathogens.

Funder

National Research Foundation Singapore

National University of Singapore

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.02615-21

Reference66 articles.

1. Capsule Prolongs Survival of Streptococcus pneumoniae during Starvation

2. Capsule Type and Amount Affect Shedding and Transmission of Streptococcus pneumoniae