High-Throughput Mutagenesis and Cross-Complementation Experiments Reveal Substrate Preference and Critical Residues of the Capsule Transporters in Streptococcus pneumoniae

Author:

Chua Wan-Zhen1ORCID,Maiwald Matthias123ORCID,Chew Kean Lee4,Lin Raymond Tzer-Pin145,Zheng Sanduo67ORCID,Sham Lok-To1ORCID

Affiliation:

1. Infectious Diseases Translational Research Programme and Department of Microbiology and Immunology, National University of Singapore, Singapore

2. Department of Pathology and Laboratory Medicine, KK Women’s and Children’s Hospital Singapore

3. Duke-NUS Graduate Medical School, National University of Singapore, Singapore

4. Department of Laboratory Medicine, National University Hospital, Singapore

5. National Public Health Laboratory, Ministry of Health, Singapore

6. National Institute of Biological Sciences, Beijing, China

7. Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing, China

Abstract

All licensed pneumococcal vaccines target the capsular polysaccharide (CPS). This layer is highly variable and is important for virulence in many bacterial pathogens.

Funder

National Research Foundation Singapore

National University of Singapore

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

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