Repeat-Unit Elongations To Produce Bacterial Complex Long Polysaccharide Chains, an O-Antigen Perspective

Author:

Hong Yaoqin12ORCID,Hu Dalong3ORCID,Verderosa Anthony D.1ORCID,Qin Jilong1ORCID,Totsika Makrina1ORCID,Reeves Peter R.2ORCID

Affiliation:

1. Centre for Immunology and Infection Control, School of Biomedical Sciences, Queensland University of Technology, Brisbane, Queensland, Australia

2. School of Life and Environmental Sciences, The University of Sydney, Camperdown, New South Wales, Australia

3. Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore

Abstract

The O-antigen, a long polysaccharide that constitutes the distal part of the outer membrane-anchored lipopolysaccharide, is one of the critical components in the protective outer membrane of Gram-negative bacteria. Most species produce one of the structurally diverse O-antigens, with nearly all the polysaccharide components having complex structures made by the Wzx/Wzy pathway.

Funder

Queensland University of Technology

Department of Education and Training | Australian Research Council

DHAC | National Health and Medical Research Council

Clive and Vera Ramaciotti Foundations

Publisher

American Society for Microbiology

Subject

Microbiology

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