Adaptation to Endoplasmic Reticulum Stress Requires Transphosphorylation within the Activation Loop of Protein Kinases Kin1 and Kin2, Orthologs of Human Microtubule Affinity-Regulating Kinase-Reference-Cited by-同舟云学术

Adaptation to Endoplasmic Reticulum Stress Requires Transphosphorylation within the Activation Loop of Protein Kinases Kin1 and Kin2, Orthologs of Human Microtubule Affinity-Regulating Kinase

Published:2018-12 Issue:23 Volume:38 Page:
ISSN:0270-7306
Container-title:Molecular and Cellular Biology
language:en
Short-container-title:Mol Cell Biol

Author:

Ghosh Chandrima¹,Sathe Leena¹,Paprocki Joel David²,Raicu Valerica¹²,Dey Madhusudan¹

Affiliation:

1. Department of Biological Sciences, University of Wisconsin—Milwaukee, Milwaukee, Wisconsin, USA

2. Department of Physics, University of Wisconsin—Milwaukee, Milwaukee, Wisconsin, USA

Abstract

Perturbations in endoplasmic reticulum (ER) homeostasis, a condition termed ER stress, activate the unfolded protein response (UPR), an intracellular network of signaling pathways. Recently, we have shown that protein kinase Kin1 and its paralog, Kin2, in the budding yeast Saccharomyces cerevisiae (orthologs of microtubule affinity-regulating kinase in humans) contribute to the UPR function.

Funder

HHS | NIH | NIH Office of the Director

Publisher

American Society for Microbiology

Subject

Cell Biology,Molecular Biology

Link

https://journals.asm.org/doi/pdf/10.1128/MCB.00266-18

Reference64 articles.

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4. Phosphorylation of Pal2 by the protein kinases Kin1 and Kin2 modulates HAC1 mRNA splicing in the unfolded protein response in yeast;Science Signaling;2021-05-25