Phosphorylation of Pal2 by the protein kinases Kin1 and Kin2 modulates HAC1 mRNA splicing in the unfolded protein response in yeast-Reference-Cited by-同舟云学术

Phosphorylation of Pal2 by the protein kinases Kin1 and Kin2 modulates HAC1 mRNA splicing in the unfolded protein response in yeast

Published:2021-05-25 Issue:684 Volume:14 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Ghosh Chandrima¹^ORCID,Uppala Jagadeesh Kumar¹^ORCID,Sathe Leena¹,Hammond Charlotte I.²^ORCID,Anshu Ashish¹,Pokkuluri P. Raj³^ORCID,Turk Benjamin E.⁴^ORCID,Dey Madhusudan¹^ORCID

Affiliation:

1. Department of Biological Sciences, University of Wisconsin-Milwaukee, Milwaukee, WI 53211, USA.

2. Department of Biological Sciences, Quinnipiac University, Hamden, CT 06518, USA.

3. Bioscience Division, Argonne National Laboratory, Lemont, IL 60439, USA.

4. Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520, USA.

Abstract

Phosphorylated Pal2 promotes the cytosolic splicing of HAC1 to restore homeostasis in yeast undergoing ER stress.

Funder

National Science Foundation

National Institutes of Health

NIH Office of the Director

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference52 articles.

1. Endoplasmic reticulum stress responses

2. The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

3. Signal integration in the endoplasmic reticulum unfolded protein response

4. Endoplasmic reticulum stress: cell life and death decisions

5. A Novel Mechanism for Regulating Activity of a Transcription Factor That Controls the Unfolded Protein Response

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