Recovery of norfloxacin in feces after administration of a single oral dose to human volunteers

Author:

Cofsky R D,duBouchet L,Landesman S H

Abstract

Twelve healthy volunteers received single 400-mg oral doses of norfloxacin. During the ensuing 48 h, from 8.3 to 53.3% (mean, 28%) of this dose was recovered in the feces. Peak drug concentrations in fecal specimens ranged from 207 to 2,716 micrograms/g.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference6 articles.

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3. In vitro antibacterial activity of nforfloxacin (MK-0366);King A.;Antimicrob. Agents Chemother.,1982

4. In vitro activity of norfloxacin, a quinolinecarboxylic acid, compared with that of - lactams, aminoglycosides, and trimethoprim;Nvu H. C.;Antimicrob. Agents Chemother.,1982

5. Antibacterial activity of norfloxacin;Norrby S. R.;Antimicrob. Agents Chemother.,1983

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