Comparative in vitro activity of norfloxacin (MK-0366) and ten other oral antimicrobial agents against urinary bacterial isolates

Author:

Khan M Y,Gruninger R P,Nelson S M,Klicker R E

Abstract

The in vitro activity of a new oral antimicrobial agent, norfloxacin (MK-0366), was compared with those of nalidixic acid, nitrofurantoin, co-trimoxazole, trimethoprim, sulfamethoxazole, cinoxacin, tetracycline, ampicillin, carbenicillin, and cephalexin against 628 urinary bacterial isolates. Norfloxacin was the most active antimicrobial agent tested against the gram-negative bacilli. It was less active than a few of the other antimicrobial agents against enterococci and Staphylococcus aureus.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference3 articles.

1. Comparative activities of AM-715 and pipemidic and nalidixic acids against experimentally induced systemic and urinary tract infections;Hhral K.;Antimicrob. Agents Chemother.,1981

2. In vitro antibacterial activity of AM-715, a new nalidixic acid analog;Ito A.;Antimicrob. Agents Chemother.,1980

3. An inocula replicating apparatus for routine testing of bacterial susceptibility to antibiotics;Steers E.;Antibiot. Chemother.,1959

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