Mutation to <i>ispA</i> Produces Stable Small-Colony Variants of Pseudomonas aeruginosa That Have Enhanced Aminoglycoside Resistance-Reference-Cited by-同舟云学术

Mutation to ispA Produces Stable Small-Colony Variants of Pseudomonas aeruginosa That Have Enhanced Aminoglycoside Resistance

Published:2022-07-19 Issue:7 Volume:66 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Pitton Melissa¹²,Oberhaensli Simone³⁴,Appiah Fiona¹,Pagani Jean-Luc⁵,Fournier Anne⁶^ORCID,Jakob Stephan M.¹,Que Yok-Ai¹^ORCID,Cameron David R.¹

Affiliation:

1. Department of Intensive Care Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland

2. Graduate School for Cellular and Biomedical Sciences (GCB), University of Bern, Bern, Switzerland

3. Interfaculty Bioinformatics Unit, University of Bern, Bern Switzerland

4. SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland

5. Service of Intensive Care Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland

6. Service of Pharmacy, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland

Abstract

Pseudomonas aeruginosa is a major pathogen in burn wound infections. We present one of the first reports of small-colony variant (SCV) emergence of P. aeruginosa , taken from a patient under aminoglycosides for a persistent burn wound infection. We confirm the causative role of a single ispA mutation in SCV emergence and increased aminoglycoside resistance. IspA is involved in the synthesis of ubiquinone, providing a possible link between electron transport and SCV formation in P. aeruginosa .

Funder

Stiftung fuer die Forchung in Anesthaesiologie und Intensivmedizin

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.00621-22

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