RNase P Inhibitors Identified as Aggregators-Reference-Cited by-同舟云学术

RNase P Inhibitors Identified as Aggregators

Published:2021-07-16 Issue:8 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Schencking Isabell¹,Schäfer Eva M.¹,Scanlan J. H. William¹²,Wenzel Benjamin M.¹,Emmerich Rolf E.¹,Steinmetzer Torsten¹,Diederich Wibke E.¹²,Schlitzer Martin¹,Hartmann Roland K.¹^ORCID

Affiliation:

1. Institut für Pharmazeutische Chemie, Philipps-Universität Marburg, Marburg, Germany

2. Zentrum für Tumor- und Immunbiologie, Philipps-Universität Marburg, Marburg, Germany

Abstract

RNase P is an essential enzyme responsible for tRNA 5′-end maturation. In most bacteria, the enzyme is a ribonucleoprotein consisting of a catalytic RNA subunit and a small protein cofactor termed RnpA. Several studies have reported small-molecule inhibitors directed against bacterial RNase P that were identified by high-throughput screenings.

Funder

LOEWE Center DRUID

Deutsche Forschungsgemeinschaft

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00300-21

Reference65 articles.

1. Chapter 8 The Making of tRNAs and More – RNase P and tRNase Z

2. Chance and necessity in the evolution of RNase P

3. The RNA moiety of ribonuclease P is the catalytic subunit of the enzyme

4. Analysis of RNase P Protein ( rnpA ) Expression in Bacillus subtilis Utilizing Strains with Suppressible rnpA Expression

5. Complementation of an RNase P RNA (rnpB) gene deletion in Escherichia coli by homologous genes from distantly related eubacteria

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1. The specificity landscape of bacterial ribonuclease P;Journal of Biological Chemistry;2024-01

2. Targeting Ribonucleases with Small Molecules and Bifunctional Molecules;ACS Chemical Biology;2023-06-29

3. Characterization of RNA-based and protein-only RNases P from bacteria encoding both enzyme types;RNA;2023-01-05