In VivoActivity of Aryl Ozonides against Schistosoma Species

Abstract

ABSTRACTWe evaluated thein vivoantischistosomal activities of 11 structurally diverse synthetic peroxides. Of all compounds tested, ozonide (1,2,4-trioxolane) OZ418 had the highest activity against adultSchistosoma mansoni, with total and female worm burden reductions of 80 and 90% (P< 0.05), respectively. Furthermore, treatment ofS. haematobium-infected mice with OZ418 reduced the total worm burden by 86%. In conclusion, OZ418 is a promising antischistosomal lead compound.