Spiro and Dispiro-1,2,4-trioxolanes as Antimalarial Peroxides: Charting a Workable Structure−Activity Relationship Using Simple Prototypes-Reference-Cited by-同舟云学术

Spiro and Dispiro-1,2,4-trioxolanes as Antimalarial Peroxides: Charting a Workable Structure−Activity Relationship Using Simple Prototypes

Published:2005-06-25 Issue:15 Volume:48 Page:4953-4961
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Dong Yuxiang¹,Chollet Jacques¹,Matile Hugues¹,Charman Susan A.¹,Chiu Francis C. K.¹,Charman William N.¹,Scorneaux Bernard¹,Urwyler Heinrich¹,Santo Tomas Josefina¹,Scheurer Christian¹,Snyder Christopher¹,Dorn Arnulf¹,Wang Xiaofang¹,Karle Jean M.¹,Tang Yuanqing¹,Wittlin Sergio¹,Brun Reto¹,Vennerstrom Jonathan L.¹

Affiliation:

1. College of Pharmacy, University of Nebraska Medical Center, 986025 Nebraska Medical Center, Omaha, Nebraska 68198-6025, Swiss Tropical Institute, Socinstrasse 57, CH-4002 Basel, Switzerland, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, CH-4070 Basel, Switzerland, Victorian College of Pharmacy, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia, Basilea Pharmaceutica Ltd., Grenzacherstrasse 487, CH-4058 Basel, Switzerland, and Division of Experimental Therapeutics, Walter Reed...

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm049040u

Reference41 articles.

1. Medical need, scientific opportunity and the drive for antimalarial drugs

2. Synthetic peroxides as antimalarials

3. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

4. Molecular Properties That Influence the Oral Bioavailability of Drug Candidates

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