Active-Site Conformational Fluctuations Promote the Enzymatic Activity of NDM-1-Reference-Cited by-同舟云学术

Active-Site Conformational Fluctuations Promote the Enzymatic Activity of NDM-1

Published:2018-11 Issue:11 Volume:62 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Zhang Hongmin¹²^ORCID,Ma Guixing¹²,Zhu Yifan¹²,Zeng Lingxiao³,Ahmad Ashfaq¹²,Wang Changzhi¹²,Pang Bo³,Fang Huiyan⁴,Zhao Liqing⁴,Hao Quan³

Affiliation:

1. Department of Biology, Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research, Southern University of Science and Technology, Shenzhen, China

2. Shenzhen Key Laboratory of Cell Microenvironment and SUSTech-HKU Joint Laboratories for Matrix Biology and Diseases, Southern University of Science and Technology, Shenzhen, China

3. School of Biomedical Sciences, The University of Hong Kong, Hong Kong SAR, China

4. College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen, Guangdong, China

Abstract

β-Lactam antibiotics are the mainstay for the treatment of bacterial infections. However, elevated resistance to these antibiotics mediated by metallo-β-lactamases (MBLs) has become a global concern.

Funder

Special Fund for Development of Strategic Emerging Industries in Shenzhen

National Natural Science Foundation of China

FHB | Health and Medical Research Fund

Research Grants Council, University Grants Committee

Guangdong Science and Technology Department

Natural Science Foundation of Guangdong Province

Shenzhen Science and Technology Innovation Commission

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology