In Vitro Susceptibility Testing of GSK656 against Mycobacterium Species

Author:

Dong Wenzhu123,Li Shanshan1,Wen Shu’an1,Jing Wei1,Shi Jin14,Ma Yifeng1,Huo Fengmin1,Gao Fei3,Pang Yu1ORCID,Lu Jie4

Affiliation:

1. National Clinical Laboratory on Tuberculosis, Beijing Key Laboratory on Drug-Resistant Tuberculosis Research, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Institute, Beijing, China

2. Department of Infectious Diseases, The First People’s Hospital of Ziyang, Ziyang, China

3. Department of Tuberculosis, The Fourth Hospital of Inner Mongolia, Hohhot, China

4. Beijing Key Laboratory for Pediatric Diseases of Otolaryngology, Head and Neck Surgery, MOE Key Laboratory of Major Diseases in Children, Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China

Abstract

In this study, we aimed to assess the in vitro susceptibility to GSK656 among multiple mycobacterial species and to investigate the correlation between leucyl-tRNA synthetase (LeuRS) sequence variations and in vitro susceptibility to GSK656 among mycobacterial species. A total of 187 mycobacterial isolates, comprising 105 Mycobacterium tuberculosis isolates and 82 nontuberculous mycobacteria (NTM) isolates, were randomly selected for the determination of in vitro susceptibility.

Funder

Tongzhou District Science and Technology Commitee

Beijing Talents Foundation

Beijing Municipal Administration of Hospitals' Youth Programme

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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