Polymerase Activity, Protein-Protein Interaction, and Cellular Localization of the Usutu Virus NS5 Protein-Reference-Cited by-同舟云学术

Polymerase Activity, Protein-Protein Interaction, and Cellular Localization of the Usutu Virus NS5 Protein

Published:2019-12-20 Issue:1 Volume:64 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Albentosa-González L.¹,Clemente-Casares P.¹²³,Sabariegos R.¹⁴³,Mas A.¹²³^ORCID

Affiliation:

1. Unidad de Medicina Molecular, Centro Regional de Investigaciones Biomédicas, Albacete, Spain

2. Facultad de Farmacia, Universidad de Castilla—La Mancha, Albacete, Spain

3. Unidad de Biomedicina UCLM-CSIC, Albacete, Spain

4. Facultad de Medicina, Universidad de Castilla—La Mancha, Albacete, Spain

Abstract

Usutu virus (USUV) has become increasingly relevant in recent years, with large outbreaks that sporadically have affected humans being reported in wildlife. Similarly to the rest of flaviviruses, USUV contains a positive-sense single-stranded RNA genome which is replicated by the activity of nonstructural protein 5 (NS5). USUV NS5 shows high sequence identity with the remaining viruses in this genus.

Funder

Ministerio de Economía, Industria y Competitividad, Gobierno de España

Ministerio de Ciencia, Innovación y Universidades

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01573-19

Reference42 articles.

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2. Usutu Virus: An Arbovirus on the Rise