Effect of Anti-Cord Factor Antibody on Experimental Tuberculosis in Mice-Reference-Cited by-同舟云学术

Effect of Anti-Cord Factor Antibody on Experimental Tuberculosis in Mice

Published:1973-01 Issue:1 Volume:7 Page:14-21
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Kato Masahiko¹

Affiliation:

1. Research Institute of Tuberculosis, Toneyama Hospital, National Sanatorium, Toyonaka, Osaka, Japan 560

Abstract

Either active immunization with trehalose-6, 6′-dimycolate (cord factor)-methylated bovine serum albumin complex or passive transfer of rabbit anti-cord factor serum induced in mice an enhanced resistance against infection with virulent human Mycobacterium tuberculosis . This suggests that the anti-cord factor antibody exerts an infection-protecting effect by neutralizing the toxic action of cord factor during the course of living virulent infection with tubercle bacilli. The protective effect of active immunization with cord factor-methylated bovine serum albumin complex and of anti-cord factor serum was found to be specific for the tuberculous infection among a number of experimental infections in mice with a variety of cytopathogenic microorganisms tested.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/iai.7.1.14-21.1973

Reference16 articles.

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3. Suppression of urethan-induced lung adenomas in mice treated with trehalose-6,6'- dimycolate (cord factor) and living Bacillus Calmette Guerin;Bekierkunst A.;Science,1971

4. Immune response to sheep red blood cells in mice pretreated with mycobacterial fractions;Bekierkunst A.;Infect. Immunity,1971

5. Studies on the virulence of tubercle bacilli. Isolation and biological properties of a constituent of virulent organisms;Bloch H.;J. Exp. Med.,1950

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