In Vitro Activity of ABT-773, a New Ketolide, against Recent Clinical Isolates of Streptococcus pneumoniae , Haemophilus influenzae , and Moraxella catarrhalis

Author:

Brueggemann Angela B.1,Doern Gary V.1,Huynh Holly K.1,Wingert Elizabeth M.1,Rhomberg Paul R.1

Affiliation:

1. Medical Microbiology Division, Department of Pathology, University of Iowa College of Medicine, Iowa City, Iowa

Abstract

ABSTRACT The in vitro activity of ABT-773 was evaluated against Streptococcus pneumoniae , Haemophilus influenzae , and Moraxella catarrhalis isolates. ABT-773 was the most active antimicrobial tested against S. pneumoniae . ABT-773 and azithromycin were equivalent in activity against H. influenzae and M. catarrhalis and more active than either clarithromycin or erythromycin.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference6 articles.

1. Doern G. V. A. B. Brueggemann H. Huynh E. Wingert and P. Rhomberg. Antimicrobial resistance with Streptococcus pneumoniae —results of 1997–98 34 center United States surveillance study. Emerg. Infect. Dis. in press.

2. Prevalence and Characterization of the Mechanisms of Macrolide, Lincosamide, and Streptogramin Resistance in Isolates of Streptococcus pneumoniae

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4. National Committee for Clinical Laboratory Standards Performance standards for antimicrobial susceptibility testing. Eighth informational supplement M100-S8. 1997 National Committee for Clinical Laboratory Standards Wayne Pa

5. A 1997–1998 national surveillance study: Moraxella catarrhalis and Haemophilus influenzae antimicrobial resistance in 34 U.S. institutions.;Richter S. S.;Int. J. Antimicrob. Agents,1999

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