Effects of subinhibitory concentrations of vancomycin and teicoplanin on adherence of staphylococci to tissue culture plates

Author:

Carsenti-Etesse H1,Durant J1,Entenza J1,Mondain V1,Pradier C1,Bernard E1,Dellamonica P1

Affiliation:

1. Infectious Disease Department, Archet Hospital, Nice, France.

Abstract

Bacterial adhesion is the first step in infection of medical devices. Staphylococcus aureus and Staphylococcus epidermidis are the pathogens recovered most often. The effects of subinhibitory concentrations of vancomycin and teicoplanin on the adherence of eight clinical strains of S. aureus and eight strains of S. epidermidis to tissue culture plates in vitro were tested. The mean relative inhibitions of adherence at one-fourth and one-eighth the MIC were statistically different for teicoplanin and vancomycin. Slime production seemed not to be involved in adherence.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference11 articles.

1. Bisno A. L. and F. A. Waldvogel (ed.). 1989. Infections associated with indwelling medical devices. American Society for Microbiology Washington D.C.

2. Adherence of coagulase-negative staphylococci to plastic tissue culture plates: a quantitative model for adherence of staphylococci to medical devices;Christensen G. D.;J. Clin. Microbiol.,1985

3. Usefulness of a test for slime production as a marker for clinically significant infections with coagulase-negative staphylococci;Davenport D. S.;J. Infect. Dis.,1986

4. Proprietes d'adherence et production de slime des staphylocoques: relation avec la pathogenicite;Etesse-Carsenti H.;Pathol. Biol.,1990

5. Lorian V. (ed.). 1986. Effect of low antibiotic concentrations on bacteria: effects on ultrastructure their virulence and susceptibility to immunodefenses p. 596-668. In Antibiotics in laboratory medicine 2nd ed. The Williams & Wilkins Co. Baltimore.

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