Imipenem Resistance in Salmonella enterica Serovar Wien Related to Porin Loss and CMY-4 β-Lactamase Production

Author:

Armand-Lefèvre L.12,Leflon-Guibout V.12,Bredin J.3,Barguellil F.4,Amor A.4,Pagès J. M.3,Nicolas-Chanoine M.-H.12

Affiliation:

1. Hôpital Ambroise Paré AP-HP, Service de Microbiologie-Hygiène, Boulogne

2. Faculté Paris Ile-de-France Ouest, Université Versailles Saint-Quentin-en-Yvelines, Versailles

3. EA2197, Enveloppe Bactérienne, Perméabilité et Antibiotiques, Faculté de Médecine, Marseille, France

4. Hôpital Militaire de Tunis, Service de Microbiologie, Tunis, Tunisia

Abstract

ABSTRACT Two multidrug-resistant Salmonella enterica serovar Wien strains (SW468 and SW1107) were isolated in 2001 in Tunis. Both strains produced the β-lactamases TEM-1, SHV-2a, and CMY-4, whereas strain SW1107 also produced the β-lactamase CTX-M-3. The imipenem-resistant strain (SW468) was totally devoid of the OmpF-immunorelated porin. Imipenem resistance was shown as being related to porin loss and CMY-4 β-lactamase production.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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