Endocarditis Caused by Highly Penicillin-Resistant Viridans Group Streptococci: Still Room for Vancomycin-Based Regimens-Reference-Cited by-同舟云学术

Endocarditis Caused by Highly Penicillin-Resistant Viridans Group Streptococci: Still Room for Vancomycin-Based Regimens

Published:2019-08 Issue:8 Volume:63 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Pericàs Juan M.¹²,Nathavitharana Ruvandhi³^ORCID,Garcia-de-la-Mària Cristina¹,Falces Carles¹,Ambrosioni Juan¹,Almela Manel¹,García-González Javier¹,Quintana Eduard¹,Marco Francesc⁴,Moreno Asunción¹,Bayer Arnold S.⁵⁶,Miró José M.¹,Karchmer Adolf W.³,

Affiliation:

1. Hospital Clínic of Barcelona, Institut d’Investigacions Biomèdiques Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain

2. Clinical Direction on Infectious Diseases and Clinical Microbiology, Hospital Universitari Arnau de Vilanova, IRB Lleida, Spain

3. Division of Infectious Diseases, Department of Internal Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA

4. Hospital Clinic of Barcelona, ISGlobal, University of Barcelona, Barcelona, Spain

5. LA Biomedical Research Institute, Torrance, California, USA

6. Geffen School of Medicine at UCLA, Los Angeles, California, USA

Abstract

Optimal treatment options remain unknown for infective endocarditis (IE) caused by penicillin-resistant (PEN-R) viridans group streptococcal (VGS) strains. The aims of this study were to report two cases of highly PEN-R VGS IE, perform a literature review, and evaluate various antibiotic combinations in vitro and in vivo .

Funder

Institut d'Investigacións Biomèdiques August Pi i Sunyer

Cubist Pharmaceuticals, Inc.

REIPI-Spanish Network for Research in Infectious Diseases

HHS | NIH | National Institute of Allergy and Infectious Diseases

EC | European Regional Development Fund

MEC | Instituto de Salud Carlos III

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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