Hemagglutinins of Avian Influenza Viruses Are Proteolytically Activated by TMPRSS2 in Human and Murine Airway Cells-Reference-Cited by-同舟云学术

Hemagglutinins of Avian Influenza Viruses Are Proteolytically Activated by TMPRSS2 in Human and Murine Airway Cells

Published:2021-09-27 Issue:20 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Bestle Dorothea¹,Limburg Hannah¹,Kruhl Diana¹,Harbig Anne¹,Stein David A.²,Moulton Hong²,Matrosovich Mikhail¹^ORCID,Abdelwhab Elsayed M.³,Stech Jürgen³^ORCID,Böttcher-Friebertshäuser Eva¹^ORCID

Affiliation:

1. Institute of Virology, Philipps University Marburg, Marburg, Germany

2. Department of Biomedical Sciences, Oregon State University, Corvallis, Oregon, USA

3. Institute of Molecular Virology and Cell Biology, Friedrich Loeffler Institute, Federal Research Institute for Animal Health, Greifswald-Insel Riems, Germany

Abstract

Human infections with avian influenza A viruses upon exposure to infected birds are frequently reported and have received attention as a potential pandemic threat. Cleavage of the envelope glycoprotein hemagglutinin (HA) by host proteases is a prerequisite for membrane fusion and essential for virus infectivity.

Funder

German Research Foundation

State of Hesse, LOEWE

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.00906-21

Reference68 articles.

1. Bat-derived influenza-like viruses H17N10 and H18N11

2. Evolution and Ecology of Influenza A Viruses