Mode of Action of Streptolydigin-Reference-Cited by-同舟云学术

Mode of Action of Streptolydigin

Published:1969-07 Issue:1 Volume:99 Page:151-155
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Siddhikol Chalongkwan¹,Erbstoeszer John W.¹,Weisblum Bernard¹

Affiliation:

1. Department of Pharmacology, University of Wisconsin Medical School, Madison, Wisconsin 53706

Abstract

Streptolydigin and rifamycin inhibit the catalytic function of ribonucleic acid (RNA) polymerase. Streptolydigin can inhibit polymerization after the reaction has started, whereas rifamycin is effective only if it is preincubated with RNA polymerase prior to the addition of substrates. The same relationships are observed with respect to these two antibiotics if the nucleoside triphosphate-pyrophosphate exchange reaction is used in the assay system. The inhibitory effect of streptolydigin is reversible by further addition of RNA polymerase but not by addition of deoxyribonucleic acid to the assay system.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jb.99.1.151-155.1969

Reference11 articles.

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3. De Boer C. A. Dietz W. S. Silver and G. M. Savage. 1956. Streptolydigin A new antimicrobial antibiotic. I. Biologic studies of streptolydigin p. 886-892. In H. Welch and F. Marti-Ibanez (ed.) Antibiotic Annual (1955-1956). Medical Encyclopedia Inc. New York.

4. Eble T. E. C. M. Large W. H. De Vries G. F. Crum and J. W. Shell. 1956. Streptolydigin a new antimicrobial antibiotic. II. Isolation and characterization p. 893-896. In H. Welch and F. Marti-Ibanez (ed.) Antibiotic Annual (1955-1956). Medical Encyclopedia Inc. New York.

5. Basis of actinomycin action. II. Effect of actinomycin on the nucleoside triphosphate-inorganic pyrophosphate exchange;Goldberg I. H.;Proc. Nat. Acad. Sci. U.S.A.,1962

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