Beyond the approved: target sites and inhibitors of bacterial RNA polymerase from bacteria and fungi-Reference-Cited by-同舟云学术

Beyond the approved: target sites and inhibitors of bacterial RNA polymerase from bacteria and fungi

Published:2022 Issue:6 Volume:39 Page:1226-1263
ISSN:0265-0568
Container-title:Natural Product Reports
language:en
Short-container-title:Nat. Prod. Rep.

Author:

Kirsch Susanne H.¹²^ORCID,Haeckl F. P. Jake¹²^ORCID,Müller Rolf¹²³^ORCID

Affiliation:

1. Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), Saarland University Campus, 66123 Saarbrücken, Germany

2. German Centre for Infection Research (DZIF), Partner Site Hannover-Braunschweig, 38124 Braunschweig, Germany

3. Department of Pharmacy, Saarland University, 66123 Saarbrücken, Germany

Abstract

Bacterial RNA polymerase is an attractive target for the development of antibacterial therapeutics. We review the mode of action of approved compounds and highlight additional emerging target sites inhibited primarily by microbial natural products.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/NP/D1NP00067E

Reference517 articles.

1. Chemotherapie der bakteriellen Infektionen

2. Effect of Rifamycin on Protein Synthesis

3. Fidaxomicin: A Review of Its Use in Patients with Clostridium difficile Infection

4. Efficacy of bicozamycin in preventing traveler's diarrhea

5. Small-Molecule Inhibitors of the NusB–NusE Protein–Protein Interaction with Antibiotic Activity

Cited by 24 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Advances in lasso peptide discovery, biosynthesis, and function;Trends in Genetics;2024-08

2. Nα‐Aroyl‐N‐Aryl‐Phenylalanine Amides: A Promising Class of Antimycobacterial Agents Targeting the RNA Polymerase;Chemistry & Biodiversity;2024-05-08

3. Oligomerization states of the Mycobacterium tuberculosis RNA polymerase core and holoenzymes;Archives of Microbiology;2024-04-22

4. Antimicrobial Lasso Peptide Cloacaenodin Utilizes a Unique TonB-Dependent Transporter to Access Susceptible Bacteria;ACS Chemical Biology;2024-03-25

5. Sulfonamidyl derivatives of sigmacidin: Protein-protein interaction inhibitors targeting bacterial RNA polymerase and sigma factor interaction exhibiting antimicrobial activity against antibiotic-resistant bacteria;Bioorganic Chemistry;2024-02