Synergistic Effect of SOS Response and GATC Methylome Suppression on Antibiotic Stress Survival in Escherichia coli-Reference-Cited by-同舟云学术

Synergistic Effect of SOS Response and GATC Methylome Suppression on Antibiotic Stress Survival in Escherichia coli

Published:2023-02-21 Issue: Volume: Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Diaz-Diaz S.¹²³^ORCID,Recacha E.¹²³,Pulido Marina R.²³,Romero-Muñoz María²,de Gregorio-Iaria B.²,Docobo-Pérez F.²⁴³,Pascual A.¹²⁴³,Rodríguez-Martínez J. M.²⁴³^ORCID

Affiliation:

1. Unidad de Enfermedades Infecciosas y Microbiología, Hospital Universitario Virgen Macarena, Seville, Spain

2. Departamento de Microbiología, Facultad de Medicina, Universidad de Sevilla, Seville, Spain

3. Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen Macarena/CSIC/Universidad de Sevilla, Seville, Spain

4. Centro de Investigación Biomédica en Red en Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, Madrid, Spain

Abstract

The suppression of the SOS response has been shown to enhance the in vitro activity of quinolones. Furthermore, Dam-dependent base methylation has an impact on susceptibility to other antimicrobials affecting DNA synthesis.

Funder

MEC | Instituto de Salud Carlos III

Spanish Network for Research in Infectious Diseases

Universidad de Sevilla

Fondo Social Europeo

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.01392-22

Reference48 articles.