Multidrug evolutionary strategies to reverse antibiotic resistance-Reference-Cited by-同舟云学术

Multidrug evolutionary strategies to reverse antibiotic resistance

Published:2016-01 Issue:6268 Volume:351 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Baym Michael¹,Stone Laura K.¹,Kishony Roy¹²

Affiliation:

1. Department of Systems Biology, Harvard Medical School, Boston, MA, USA.

2. Department of Biology and Department of Computer Science, Technion - Israel Institute of Technology, Haifa, Israel.

Abstract

Evolving antibiotic rescue stratagems Antibiotic resistance threatens to put modern medicine into reverse. But we are not at the end of our options for currently available drugs. Baym et al. review what can be done by using combinations of antibiotics to circumvent bacteria's evolutionary strategies. For instance, resistance to one drug may cause sensitivity to another, the effectiveness of two drugs can be synergized by a resistance mutation, and some negative drug interactions may even be beneficial in selecting against resistance. Although not simple to assess, drug combinations still have something to offer for the development of sorely needed anti-infectives. Science , this issue p. 10.1126/science.aad3292

Funder

U.S. National Institutes of Health

European Research Council

F. Hoffmann-La Roche Ltd

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference123 articles.

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3. Antibiotic effectiveness: Balancing conservation against innovation

4. President’s Council of Advisors on Science Technology “Report to the President on Combating Antibiotic Resistance” (Executive Office of the President 2014) pp. 1–78.

5. World Health Organization “Antimicrobial resistance: Global report on surveillance” (World Health Organization Geneva Switzerland 2014).

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