Macrodomain Binding Compound MRS 2578 Inhibits Alphavirus Replication-Reference-Cited by-同舟云学术

Macrodomain Binding Compound MRS 2578 Inhibits Alphavirus Replication

Published:2021-11-17 Issue:12 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Mattila Sari¹,Merilahti Pirjo¹,Wazir Sarah²,Quirin Tania¹,Maksimainen Mirko M.²³,Zhang Yuezhou⁴,Xhaard Henri⁴,Lehtiö Lari²³,Ahola Tero¹^ORCID

Affiliation:

1. Department of Microbiology, Faculty of Agriculture and Forestry, University of Helsinki, Helsinki, Finland

2. Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland

3. Biocenter Oulu, University of Oulu, Oulu, Finland

4. Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland

Abstract

Alphaviruses are positive-strand RNA viruses causing febrile disease. Macrodomain-containing proteins, involved in ADP-ribose-mediated signaling, are encoded by both host cells and several virus groups, including alphaviruses.

Funder

Academy of Finland

Sigrid Juséliuksen Säätiö

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01398-21

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