Discovery of 2-Amide-3-methylester Thiophenes that Target SARS-CoV-2 Mac1 and Repress Coronavirus Replication, Validating Mac1 as an Antiviral Target-Reference-Cited by-同舟云学术

Discovery of 2-Amide-3-methylester Thiophenes that Target SARS-CoV-2 Mac1 and Repress Coronavirus Replication, Validating Mac1 as an Antiviral Target

Published:2024-04-09 Issue:8 Volume:67 Page:6519-6536
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Wazir Sarah¹,Parviainen Tomi A. O.²^ORCID,Pfannenstiel Jessica J.³,Duong Men Thi Hoai¹,Cluff Daniel³,Sowa Sven T.¹,Galera-Prat Albert¹,Ferraris Dana⁴^ORCID,Maksimainen Mirko M.¹,Fehr Anthony R.³,Heiskanen Juha P.²^ORCID,Lehtiö Lari¹^ORCID

Affiliation:

1. Faculty of Biochemistry and Molecular Medicine & Biocenter Oulu, University of Oulu, 90220 Oulu, Finland

2. Research Unit of Sustainable Chemistry, University of Oulu, P.O. Box 4300, 90014 Oulu, Finland

3. Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas 66045, United States

4. McDaniel College Department of Chemistry, 2 College Hill, Westminster, Maryland 21157, United States

Funder

U.S. Department of Health and Human Services

Emil Aaltosen S????ti??

Sigrid Jus??liuksen S????ti??

Oulun Yliopisto

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c02451

Reference50 articles.

1. Coronaviruses: An Updated Overview of Their Replication and Pathogenesis

2. Regulation of type I interferon responses

3. Evolutionary insights into host–pathogen interactions from mammalian sequence data

4. Intracellular mono-ADP-ribosyltransferases at the host–virus interphase

5. The impact of PARPs and ADP-ribosylation on inflammation and host–pathogen interactions

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1. Discovery of potent SARS-CoV-2 nsp3 macrodomain inhibitors uncovers lack of translation to cellular antiviral response;2024-08-21

2. The Mac1 ADP-ribosylhydrolase is a Therapeutic Target for SARS-CoV-2;2024-08-09