Affiliation:
1. Fisch College of Pharmacy, The University of Texas at Tyler, Tyler, Texas, USA
Abstract
ABSTRACT
Staphylococcus aureus
poses a serious global threat to human health due to its pathogenic nature, adaptation to environmental stress, high virulence, and the prevalence of antimicrobial resistance. The signaling network in
S. aureus
coordinates and integrates various internal and external inputs and stimuli to adapt and formulate a response to the environment. Two-component systems (TCSs) of
S. aureus
play a central role in this network where surface-expressed histidine kinases (HKs) receive and relay external signals to their cognate response regulators (RRs). Despite the purported high fidelity of signaling, crosstalk within TCSs, between HK and non-cognate RR, and between TCSs and other systems has been detected widely in bacteria. The examples of crosstalk in
S. aureus
are very limited, and there needs to be more understanding of its molecular recognition mechanisms, although some crosstalk can be inferred from similar bacterial systems that share structural similarities. Understanding the cellular processes mediated by this crosstalk and how it alters signaling, especially under stress conditions, may help decipher the emergence of antibiotic resistance. This review highlights examples of signaling crosstalk in bacteria in general and
S. aureus
in particular, as well as the effect of TCS mutations on signaling and crosstalk.
Funder
HHS | NIH | National Institute of Allergy and Infectious Diseases
University of Texas at Tyler
Publisher
American Society for Microbiology
Cited by
2 articles.
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