Pharmacokinetics of Itraconazole Oral Solution in Neutropenic Children during Long-Term Prophylaxis-Reference-Cited by-同舟云学术

Pharmacokinetics of Itraconazole Oral Solution in Neutropenic Children during Long-Term Prophylaxis

Published:2001-05 Issue:5 Volume:45 Page:1561-1564
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Schmitt Claudine¹,Perel Yves²,Harousseau Jean-luc³,Lemerle Sophie⁴,Chwetzoff Elisabeth⁵,le Moing Jean-Pierre⁵,Levron Jean-Claude⁵

Affiliation:

1. Hôpital d'Enfants, Vandoeuvre les Nancy,1

2. Hôpital Pellegrin, Bordeaux,2

3. Hôtel Dieu, Nantes,3

4. Hôpital Intercommunal, Créteil,4 and

5. Janssen Research Foundation, Val de Reuil,5 France

Abstract

ABSTRACT We investigated the pharmacokinetics and safety of an oral solution of itraconazole in two groups of neutropenic children stratified by age. Effective concentrations of itraconazole in plasma were reached quickly and maintained throughout treatment. The results indicate a trend toward higher concentrations of itraconazole in plasma in older children.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.45.5.1561-1564.2001

Reference18 articles.

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5. Itraconazole through concentrations in antifungal prophylaxis with six different dosing regimens using hydroxypropyl-β-cyclodextrin oral solution or coated-pellet capsules.;Glasmacher A.;Mycoses,1999

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