Potency and Preclinical Evidence of Synergy of Oral Azole Drugs and Miltefosine in an Ex Vivo Model of Leishmania ( Viannia ) panamensis Infection-Reference-Cited by-同舟云学术

Potency and Preclinical Evidence of Synergy of Oral Azole Drugs and Miltefosine in an Ex Vivo Model of Leishmania ( Viannia ) panamensis Infection

Published:2022-01-18 Issue:1 Volume:66 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Fernández Olga Lucía¹²^ORCID,Rosales-Chilama Mariana¹²,Quintero Natali¹²,Travi Bruno L.³,Wetzel Dawn M.⁴⁵,Gómez María Adelaida¹²,Saravia Nancy Gore¹²

Affiliation:

1. Centro Internacional de Entrenamiento e Investigaciones Médicas (CIDEIM), Cali, Colombia

2. Universidad Icesi, Cali, Colombia

3. Division of Infectious Diseases, Department of Internal Medicine, University of Texas Medical Branch (UTMB), Galveston, Texas, USA

4. Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA

5. Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas, USA

Abstract

Failure of treatment of cutaneous leishmaniasis with antimonial drugs and miltefosine is frequent. Use of oral combination therapy represents an attractive strategy to increase efficacy of treatment and reduce the risk of drug resistance.

Funder

Departamento Administrativo de Ciencia, Tecnología e Innovación

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01425-21

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4. Noninferiority of Miltefosine Versus Meglumine Antimoniate for Cutaneous Leishmaniasis in Children

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