Differential Expression of the Middle East Respiratory Syndrome Coronavirus Receptor in the Upper Respiratory Tracts of Humans and Dromedary Camels-Reference-Cited by-同舟云学术

Differential Expression of the Middle East Respiratory Syndrome Coronavirus Receptor in the Upper Respiratory Tracts of Humans and Dromedary Camels

Published:2016-05 Issue:9 Volume:90 Page:4838-4842
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Widagdo W.¹,Raj V. Stalin¹,Schipper Debby¹,Kolijn Kimberley²,van Leenders Geert J. L. H.²,Bosch Berend J.³,Bensaid Albert⁴,Segalés Joaquim⁵⁶,Baumgärtner Wolfgang⁷,Osterhaus Albert D. M. E.¹⁸⁹,Koopmans Marion P.¹,van den Brand Judith M. A.¹,Haagmans Bart L.¹

Affiliation:

1. Department of Viroscience, Erasmus MC, Rotterdam, The Netherlands

2. Department of Pathology, Erasmus MC, Rotterdam, The Netherlands

3. Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands

4. IRTA, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona, Bellaterra (Cerdanyola del Vallès), Spain

5. UAB, Centre de Recerca en Sanitat Animal (CReSA), Unitat Mixta IRTA-UAB, Campus de la Universitat Autònoma de Barcelona, Bellaterra (Cerdanyola del Vallès), Spain

6. Departament de Sanitat i Anatomia Animals, Facultat de Veterinària, Universitat Autònoma de Barcelona, Bellaterra (Cerdanyola del Vallès), Spain

7. Department of Pathology, University of Veterinary Medicine, Hannover, Germany

8. Artemis One Health, Utrecht, The Netherlands

9. Center for Infection Medicine and Zoonoses Research (RIZ), University of Veterinary Medicine, Hannover, Germany

Abstract

ABSTRACT Middle East respiratory syndrome coronavirus (MERS-CoV) is not efficiently transmitted between humans, but it is highly prevalent in dromedary camels. Here we report that the MERS-CoV receptor—dipeptidyl peptidase 4 (DPP4)—is expressed in the upper respiratory tract epithelium of camels but not in that of humans. Lack of DPP4 expression may be the primary cause of limited MERS-CoV replication in the human upper respiratory tract and hence restrict transmission.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.02994-15

Reference28 articles.

1. State of Knowledge and Data Gaps of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) in Humans

2. WHO. 2015. Middle East respiratory syndrome (MERS) in the Republic of Korea. World Health Organization, Geneva, Switzerland. http://www.who.int/csr/disease/coronavirus_infections/situation-assessment/update-15-06-2015/en/.

3. MERS coronavirus in dromedary camel herd, Saudi Arabia;Hemida MG;Emerg Infect Dis,2014

4. Isolation of MERS coronavirus from a dromedary camel, Qatar, 2014;Raj VS;Emerg Infect Dis,2014

5. Presence of Middle East respiratory syndrome coronavirus antibodies in Saudi Arabia: a nationwide, cross-sectional, serological study

Cited by 120 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Resistance to SARS-CoV-2 infection in camelid nasal organoids is associated with lack of ACE2 expression;npj Viruses;2024-09-02

2. MERS-CoV remains a persistent threat amid global events;Journal of Infection and Public Health;2024-08

3. Symptom propagation in respiratory pathogens of public health concern: a review of the evidence;Journal of The Royal Society Interface;2024-07

4. Inactivated Split MERS-CoV Antigen Prevents Lethal Middle East Respiratory Syndrome Coronavirus Infections in Mice;Vaccines;2024-04-18

5. Symptom propagation in respiratory pathogens of public health concern: a review of the evidence;2024-01-07