Postneurosurgical Meningitis Due to Proteus penneri with Selection of a Ceftriaxone-Resistant Isolate: Analysis of Chromosomal Class A β-Lactamase HugA and its LysR-Type Regulatory Protein HugR-Reference-Cited by-同舟云学术

Postneurosurgical Meningitis Due to Proteus penneri with Selection of a Ceftriaxone-Resistant Isolate: Analysis of Chromosomal Class A β-Lactamase HugA and its LysR-Type Regulatory Protein HugR

Published:2002-01 Issue:1 Volume:46 Page:216-219
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Liassine Nadia¹,Madec Stéphanie²,Ninet Béatrice¹,Metral Catherine¹,Fouchereau-Peron Martine³,Labia Roger²,Auckenthaler Raymond¹

Affiliation:

1. Central Laboratory of Bacteriology, University Hospital, Geneva, Switzerland

2. Centre National de la Recherche Scientifique, Unité FRE 2125, Quimper

3. Centre de Biologie Marine, Unité FRE 2125, Concarneau, France

Abstract

ABSTRACT We report on a case of a postneurosurgical meningitis due to ceftriaxone-susceptible Proteus penneri , with selection of a ceftriaxone-resistant isolate following treatment with ceftriaxone. The isolates presented identical patterns by pulsed-field gel electrophoresis and produced a single β-lactamase named HugA with an isoelectric point of 6.7. The ceftriaxone-resistant isolate hyperproduced the β-lactamase (increase in the level of production, about 90-fold). The sequences of the hugA β-lactamase gene and its regulator, hugR , were identical in both P. penneri strains and had 85.96% homology with those of Proteus vulgaris . The HugA β-lactamase belongs to molecular class A, and the transcriptional regulator HugR belongs to the LysR family.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.46.1.216-219.2002

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