Affiliation:
1. Departments of Pathology
2. Epidemiology
3. Internal Medicine, Roy J. and Lucille A. Carver College of Medicine and College of Public Health, University of Iowa, Iowa City, Iowa 52242
Abstract
ABSTRACT
We performed 24- and 48-h MIC determinations and disk diffusion testing of fluconazole against more than 11,000 clinical isolates of
Candida
species. By using the reference MIC breakpoints, the categorical agreement between the 24-h and reference 48-h broth microdilution results ranged from 93.8% (all
Candida
species) to 94.9% (all
Candida
species minus
Candida krusei
), with only 0.1% very major errors (VME). The essential agreement (within 2 log
2
dilutions) between the 24-h and 48-h results was 99.6%. The categorical agreement between the 24-h disk diffusion results and the 24-h MIC results, using the previously established breakpoints, was 94.4%, with 0.1% VME. Both the MIC and the disk diffusion results obtained for fluconazole after only 24 h of incubation may be used to determine the susceptibilities of
Candida
spp. to this widely used antifungal agent.
Publisher
American Society for Microbiology
Cited by
39 articles.
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