Pyrazinamide Resistance and pncA Gene Mutations in Mycobacterium tuberculosis-Reference-Cited by-同舟云学术

Pyrazinamide Resistance and pncA Gene Mutations in Mycobacterium tuberculosis

Published:2008-05 Issue:5 Volume:52 Page:1852-1854
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Juréen Pontus¹²,Werngren Jim¹,Toro Juan-Carlos¹,Hoffner Sven¹

Affiliation:

1. Department of Bacteriology, Swedish Institute for Infectious Disease Control, Solna

2. Department of Microbiology, Tumour and Cell Biology Center, Karolinska Institute, Stockholm, Sweden

Abstract

ABSTRACT Thirty-four pyrazinamide-resistant and 37 pyrazinamide-susceptible Mycobacterium tuberculosis complex strains were analyzed for pncA gene mutations. None of the sensitive strains had any mutations, apart from silent mutations, whereas all but one resistant strain showed pncA mutations. By using sequencing as a means of early resistance detection, the inconsistency of phenotypic pyrazinamide assays can be circumvented.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00110-08

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