LncRNA XR_001779380 Primes Epithelial Cells for IFN-γ-Mediated Gene Transcription and Facilitates Age-Dependent Intestinal Antimicrobial Defense-Reference-Cited by-同舟云学术

LncRNA XR_001779380 Primes Epithelial Cells for IFN-γ-Mediated Gene Transcription and Facilitates Age-Dependent Intestinal Antimicrobial Defense

Published:2021-10-26 Issue:5 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Gong Ai-Yu¹²,Wang Yang²,Li Min²,Zhang Xin-Tian²,Deng Silu¹²,Chen Jessie M.²,Lu Eugene²,Mathy Nicholas W.²,Martins Gislaine A.³,Strauss-Soukup Juliane K.⁴,Chen Xian-Ming¹²^ORCID

Affiliation:

1. Department of Microbial Pathogens and Immunity, Rush University Medical Center, Chicago, Illinois, USA

2. Department of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, Nebraska, USA

3. Deptartments of Medicine and Biomedical Sciences, Research Division of Immunology Cedars-Sinai Medical Center, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA

4. Department of Chemistry, Creighton University College of Arts and Sciences, Omaha, Nebraska, USA

Abstract

Epithelial cells along the mucosal surface provide the front line of defense against luminal pathogen infection in the gastrointestinal tract. These epithelial cells represent an integral component of a highly regulated communication network that can transmit essential signals to cells in the underlying intestinal mucosa that, in turn, serve as targets of mucosal immune mediators.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.02127-21

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