SERINC5 Can Enhance Proinflammatory Cytokine Production by Primary Human Myeloid Cells in Response to Challenge with HIV-1 Particles-Reference-Cited by-同舟云学术

SERINC5 Can Enhance Proinflammatory Cytokine Production by Primary Human Myeloid Cells in Response to Challenge with HIV-1 Particles

Published:2021-04-12 Issue:9 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Pierini Virginia¹,Gallucci Lara¹,Stürzel Christina M.²,Kirchhoff Frank²^ORCID,Fackler Oliver T.¹³^ORCID

Affiliation:

1. Department of Infectious Diseases, Integrative Virology, University Hospital Heidelberg, Heidelberg, Germany

2. Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany

3. German Centre for Infection Research (DZIF), Partner Site Heidelberg, Heidelberg, Germany

Abstract

SERINC5 (S5) is a host cell restriction factor (RF) that impairs the infectivity of HIV-1 particles in target cell lines. To assess the potential physiological relevance of this restriction, we assessed the effects of S5 on HIV-1 infection of relevant primary human target cells.

Funder

Deutsche Forschungsgemeinschaft

Deutsches Zentrum für Infektionsforschung

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.02372-20

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2. Innate immunity against HIV-1 infection