Methylthioadenosine Suppresses Salmonella Virulence-Reference-Cited by-同舟云学术

Methylthioadenosine Suppresses Salmonella Virulence

Published:2018-09 Issue:9 Volume:86 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Bourgeois Jeffrey S.¹²,Zhou Daoguo³,Thurston Teresa L. M.⁴,Gilchrist James J.⁵⁶,Ko Dennis C.¹²⁷^ORCID

Affiliation:

1. Department of Molecular Genetics and Microbiology, School of Medicine, Duke University, Durham, North Carolina, USA

2. University Program in Genetics and Genomics, Duke University, Durham, North Carolina, USA

3. Department of Biological Sciences, Purdue University, West Lafayette, Indiana, USA

4. Section of Microbiology, Centre for Molecular Microbiology and Infection, Imperial College London, London, United Kingdom

5. Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

6. Department of Paediatrics, University of Oxford, Oxford, United Kingdom

7. Division of Infectious Diseases, Department of Medicine, School of Medicine, Duke University, Durham, North Carolina, USA

Abstract

In order to deploy virulence factors at appropriate times and locations, microbes must rapidly sense and respond to various metabolite signals. Previously, we showed a transient elevation of the methionine-derived metabolite methylthioadenosine (MTA) concentration in serum during systemic Salmonella enterica serovar Typhimurium infection.

Funder

Wellcome Trust

HHS | National Institutes of Health

HHS | NIH | National Institute of Allergy and Infectious Diseases

Imperial College London

Duke University

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00429-18