Integration of the <i>Salmonella</i> Typhimurium Methylome and Transcriptome Reveals That DNA Methylation and Transcriptional Regulation Are Largely Decoupled under Virulence-Related Conditions-Reference-Cited by-同舟云学术

Integration of the Salmonella Typhimurium Methylome and Transcriptome Reveals That DNA Methylation and Transcriptional Regulation Are Largely Decoupled under Virulence-Related Conditions

Published:2022-06-28 Issue:3 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Bourgeois Jeffrey S.¹²^ORCID,Anderson Caroline E.¹,Wang Liuyang¹,Modliszewski Jennifer L.³,Chen Wei³,Schott Benjamin H.¹²,Devos Nicolas³,Ko Dennis C.¹²⁴^ORCID

Affiliation:

1. Department of Molecular Genetics and Microbiology, School of Medicine, Duke University, Durham, North Carolina, USA

2. University Program in Genetics and Genomics, Duke University, Durham, North Carolina, USA

3. Center for Genomics and Computational Biology, Duke University, Durham, North Carolina, USA

4. Division of Infectious Diseases, Department of Medicine, School of Medicine, Duke University, Durham, North Carolina, USA

Abstract

While recent breakthroughs have enabled intense study of bacterial DNA modifications, limitations in current work have potentiated a surprisingly untested narrative that DNA methylation is a common mechanism of the bacterial response to environmental conditions. Essentially, whether epigenetic regulation of bacterial transcription is a common, generalizable phenomenon is a critical unanswered question that we address here.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.03464-21

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