Dissecting Naturally Arising Amino Acid Substitutions at Position L452 of SARS-CoV-2 Spike-Reference-Cited by-同舟云学术

Dissecting Naturally Arising Amino Acid Substitutions at Position L452 of SARS-CoV-2 Spike

Published:2022-10-26 Issue:20 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Tan Toong Seng¹²,Toyoda Mako¹²,Ode Hirotaka³,Barabona Godfrey¹,Hamana Hiroshi⁴,Kitamatsu Mizuki⁵,Kishi Hiroyuki⁴,Motozono Chihiro¹²,Iwatani Yasumasa³^ORCID,Ueno Takamasa¹²^ORCID

Affiliation:

1. Joint Research Center for Human Retrovirus Infection, Kumamoto University, Kumamoto, Japan

2. Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan

3. Clinical Research Center, National Hospital Organization Nagoya Medical Center, Nagoya, Aichi, Japan

4. Department of Immunology, Faculty of Medicine, Academic Assembly, University of Toyama, Toyama, Japan

5. Department of Applied Chemistry, Faculty of Science and Engineering, Kindai University, Osaka, Japan

Abstract

In a span of less than 3 years since the declaration of the coronavirus pandemic, numerous SARS-CoV-2 variants of concern have emerged all around the globe, fueling a surge in the number of cases and deaths that caused severe strain on the health care system. A major concern is whether viral evolution eventually promotes greater fitness advantages, transmissibility, and immune escape.

Funder

Japan Agency for Medical Research and Development

MEXT | Japan Society for the Promotion of Science

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.01162-22

Reference50 articles.

1. Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor

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