Dissecting Naturally Arising Amino Acid Substitutions at Position L452 of SARS-CoV-2 Spike

Author:

Tan Toong Seng12,Toyoda Mako12,Ode Hirotaka3,Barabona Godfrey1,Hamana Hiroshi4,Kitamatsu Mizuki5,Kishi Hiroyuki4,Motozono Chihiro12,Iwatani Yasumasa3ORCID,Ueno Takamasa12ORCID

Affiliation:

1. Joint Research Center for Human Retrovirus Infection, Kumamoto University, Kumamoto, Japan

2. Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan

3. Clinical Research Center, National Hospital Organization Nagoya Medical Center, Nagoya, Aichi, Japan

4. Department of Immunology, Faculty of Medicine, Academic Assembly, University of Toyama, Toyama, Japan

5. Department of Applied Chemistry, Faculty of Science and Engineering, Kindai University, Osaka, Japan

Abstract

In a span of less than 3 years since the declaration of the coronavirus pandemic, numerous SARS-CoV-2 variants of concern have emerged all around the globe, fueling a surge in the number of cases and deaths that caused severe strain on the health care system. A major concern is whether viral evolution eventually promotes greater fitness advantages, transmissibility, and immune escape.

Funder

Japan Agency for Medical Research and Development

MEXT | Japan Society for the Promotion of Science

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3