Salivaricin P, One of a Family of Two-Component Antilisterial Bacteriocins Produced by Intestinal Isolates of Lactobacillus salivarius

Author:

Barrett Eoin12,Hayes Maria13,O'Connor Paula1,Gardiner Gillian12,Fitzgerald Gerald F.23,Stanton Catherine12,Ross R. Paul12,Hill Colin23

Affiliation:

1. Teagasc Biotechnology Centre, Moorepark Food Research Centre, Fermoy, County Cork, Ireland

2. Alimentary Pharmabiotic Centre, Biosciences Institute

3. Department of Microbiology, University College Cork, County Cork, Ireland

Abstract

ABSTRACT Lactobacillus salivarius DPC6005, a porcine intestinal isolate, produces a two-component bacteriocin, salivaricin P, with homology to ABP-118 produced by a human probiotic L. salivarius strain. Indeed, molecular characterization revealed that while the peptides Sln1 and ABP-118α are identical, their companion peptides (Sln2 and ABP-118β, respectively) differ by two amino acids. This observation suggests that two-component bacteriocins may be a common feature of intestinal L. salivarius strains.

Publisher

American Society for Microbiology

Subject

Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology

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