Suicidal Phenotype of Proofreading-Deficient Herpes Simplex Virus 1 Polymerase Mutants-Reference-Cited by-同舟云学术

Suicidal Phenotype of Proofreading-Deficient Herpes Simplex Virus 1 Polymerase Mutants

Published:2023-01-31 Issue:1 Volume:97 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Brunialti Marika¹,Höfler Thomas¹^ORCID,Nascimento Mariana¹,Trimpert Jakob¹^ORCID

Affiliation:

1. Institut für Virologie, Freie Universität Berlin, Berlin, Germany

Abstract

Recovery of fully exonuclease-deficient herpes simplex virus 1 (HSV-1) DNA polymerase mutants has been so far unsuccessful. However, exonuclease activity is not known to be directly essential for virus replication, and the lethal phenotype of certain HSV-1 polymerase mutants is thus attributed to factors other than exonuclease activity.

Funder

Volkswagen Foundation

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.01359-22

Reference58 articles.

1. ICTV Virus Taxonomy Profile: Herpesviridae 2021

2. The herpes simplex virus DNA polymerase: Analysis of the functional domains

4. Human DNA polymerase alpha gene expression is cell proliferation dependent and its primary structure is similar to both prokaryotic and eukaryotic replicative DNA polymerases.

5. Polymerization activity of an alpha-like DNA polymerase requires a conserved 3'-5' exonuclease active site

Cited by 2 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Evolutionary Dynamics of Accelerated Antiviral Resistance Development in Hypermutator Herpesvirus;Molecular Biology and Evolution;2024-06-16

2. Mucin‐Inspired Polymeric Fibers for Herpes Simplex Virus Type 1 Inhibition;Macromolecular Bioscience;2024-06-06